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Otitis Media (Ear Infection) (page 5)

National Institute of Mental Health

What research is being done on otitis media?

Several avenues of research are being explored to further improve the prevention, diagnosis, and treatment of otitismedia. For example, research is better defining those children who are at high risk for developing otitis media and conditions that predispose certain individuals to middle ear infections. Emphasis is being placed on discovering the reasons why some children have more ear infections than other children. The effects of otitis media on children's speech and language development are important areas of study, as is research to develop more accurate methods to help physicians detect middle ear infections. How the defense molecules and cells involved with immunity respond to bacteria and viruses that often lead to otitis media is also under investigation. Scientists are evaluating the success of certain drugs currently being used for the treatment of otitis media and are examining new drugs that may be more effective, easier to administer, and better at preventing new infections. Most important, research is leading to the availability of vaccines that will prevent otitis media.

**There is ongoing scientific discussion about the use and potential overuse of antibiotic therapy for otitis media. For further information, please note the following publications. 

 

Berman S, Byrns PJ, Bondy J, Smith PJ, Lezotte D. Otitis media-related antibiotic prescribing patterns, outcomes, and expenditures in a pediatric Medicaid population. Pediatrics. 4 Oct 1997. 100(4): 585-592.

Culpepper L, Froom J. Routine antimicrobial treatment of acute otitis media: is it necessary? JAMA. 26 Nov 1997. 278(20): 1643-1645.

Dagan R, Leibovitz E, Leiberman A, Yagupsky P. Clinical significance of antibiotic resistance in acute otitis media and implication of antibiotic treatment on carriage and spread of resistant organisms. Pediatr Infect Dis J. 19 May 2000. 19(5 Suppl): S57-S65.

Dowell SF, Butler JC, Giebink GS, Jacobs MR, Jernigan D, Musher DM, Rakowsky A, Schwartz B. Acute otitis media: management and surveillance in an era of pneumococcal resistance-a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group. Pediatr Infect Dis J. Jan 1999. 18(1): 1-9.

Ehrlich GD, Veeh R, Wang X, Costerton JW, Hayes JD, Hu FZ, Daigle BJ, Ehrich MD, Post JC. Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media. JAMA. April 2002. 287(13): 1710-1715.

Glasziou PP, Hayem M, Del Mar CB. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2000. 2: CD000219.

Kozyrskyj AL, Hildes-Ripstein GE, Longstaffe SE, Wincott JL, Sitar DS, Klassen TP, Moffatt ME. Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis. JAMA. 3 Jun 1998. 279(21): 1736-1742.

Little P, Gould C, Moore M, Warner G, Dunleavey J, Williamson I. Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. BMJ. #6 July 2002. 325(7354): 22-24.

Maw R, Wilks J, Harvey I, Peters TJ, Golding J. Early surgery compared with watchful waiting for glue ear and effect on language development in preschool children: a randomised trial. Lancet. 20 Mar 1999. 353 (9157): 960-963.

McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA. 19 June 2002. 287(23): 3096-3102.

Otitis Media with Effusion in Young Children, Changes in antibiotic prescribing for children after a community-wide campaign. JAMA. 19 June 2002. 287(23): 3103-3109.

Pichichero ME. Acute otitis media: part II. Treatment in an era of increasing antibiotic resistance. Am Fam Physician. 15 April 2000. 61(8): 2410-2416.

Rosenfeld RM, Vertrees JE, Carr J, Cipolle RJ, Uden DL, Giebink GS, Canafax DM. Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials. J Pediatrics. Mar 1994. 124(3): 355-367.

Stine AR. Is amoxicillin more effective than placebo in treating acute otitis media in children younger than 2 years? J Fam Pract. May 2000. 49(5): 465-466.

Where can I get additional information?

Agency for Healthcare Research and Quality (AHRQ)
540 Gaither Road
Rockville, MD 20850
Voice: (301) 427-1364
Toll-free Voice: (800) 358-9295
Toll-Free TTY: (888) 586-6340
E-mail: info@ahrq.gov
Internet: www.ahrq.gov

American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)
One Prince Street
Alexandria, VA 22314-3357
Voice: (703) 836-4444
TTY: (703) 519-1585
Fax: (703) 683-5100
E-mail: webmaster@entnet.org
Internet: www.entnet.org

American Speech-Language-Hearing Association (ASHA)
10801 Rockville Pike
Rockville, MD 20852
Voice: (301) 897-5700
Toll-free Voice: (800) 638-8255
TTY: (301) 897-0157
Fax: (301) 571-0457
E-mail: actioncenter@asha.org
Internet: www.asha.org

For more information, contact the NIDCD Information Clearinghouse.

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